In fact, it’s not just this
particular bug that we need to be concerned about. There are other cousins of mucor lurking in our environment,
waiting for the perfect storm of a host to take residence in. Ever wonder what
that black powdery mould that you find on old bread is? It’s Mucor, it’s Aspergillus, it’s Penicillium-
all of these are ubiquitous in our environment and are harmless to humans,
until a person with a compromised immune system comes in close proximity.
Whether it’s from infections (like HIV or TB), chemotherapy, immuno-modulators
(treatment for autoimmune diseases), or systemic steroids, of if the body’s
normal security guards (white blood cells, antibodies, natural killer cells,
etc) have been beaten down, and the fungal infections are able to take over.
Let’s take a closer look at why this happens, and, more importantly, how it can
be prevented! Because, we all know that a second pandemic via an *avoidable*
foe, is the opposite of what the global population needs right now.
I remember vividly, in my second
year of residency, the first month working on the oncology ward. Invasive
fungal infections like Mucor, and
other ‘opportunistic’ infections, are no stranger to docs that take care of
these patients daily. It is a well known complication of chemotherapy (“chemo”)
- that is - medications that purposely suppress the rapid-growing cancer cells.
It’s important to know that in addition to killing the cancer cells, chemo also
kills off other rapidly growing cells - including the body’s natural defence -
the ‘good’ bacteria, the antibodies and anti-viral compound producing white
blood cells. In fact, we would watch a patient’s white blood cell count very
carefully, and as soon as it dipped below a critical threshold- they were
placed on antifungal prophylaxis (antifungal medications to prevent infection).
Unfortunately, some of the more powerful moulds were able to break through, and
we'd have to step up the therapy to stronger medications. You may have heard of
Amphotericin B- the most effective treatment for mucormycosis and most of these other dangerous infections. In
medicine, we call this drug by an ominous pet name of “Ampho-terrible”. Why?
Yes, it kills off the fungus, but it also wreaks havoc on multiple organ
systems- particularly the kidneys, gastrointestinal tract and cardiovascular
system. Quite often, we’d lose patients not to the infection itself, but to the
side effects from treatment.
Why do I bring up these particular
side effects- just to scare you? Actually, yes! To scare you and inform you. It
is very important to understand that although many anti-infection medications
are effective, they can have negative aspects as well. Someone may think, “I’m
not afraid of black mould- there is an effective treatment!”. The problem is,
that treatment can ultimately be more harmful than good, especially long term.
Your infection will clear up, but you may end up stuck to a hemodialysis
machine (what we use for patients in end-stage kidney failure). Another concern
is that of antifungal resistance- similar to antibiotic resistance, which you
may have heard of. Too much use of a particular anti-infective, will allow some
bugs to escape the medication and eventually become immune, or resistant to it.
These super-bugs (bacteria, fungi, moulds and of course viruses) are what us
doctors and medical researchers are afraid of the most!
So, how can mucormycosis and similar opportunistic infections be prevented from
taking up residence in the body and causing serious illness? The most obvious
step is prevention- keeping a healthy active immune system will ensure that you
steer clear of these bugs. In some cases, as I mentioned earlier, suppressing
the immune system is unavoidable (cancer, HIV, etc). But there are other cases
where choices in treatment are available, and the decision needs to be made keeping these risks in mind! I am
referring, in this case, to COVID-19 treatment. One of the mainstays over the
past few months (as the treatment is, of course, evolving), has been steroid
treatment. The thought behind is that steroids will suppress the body’s
overzealous immune response to the virus, and thus improve the patient’s
condition. However, when considering steroids, it is extremely important to know when (and if!) to use them. As with
antibiotic overuse, it is dangerous to just prescribe steroids to every single
COVID positive patient. The course of
the disease is now fairly well known, and this should guide the treatment
parameters. The first few days (usually day 1-6) are when the virus is
replicating (increasing in number) in the body and causing fever, body aches,
fatigue, etc. The following week, in some cases, is when the body will try to
kill the virus, but often overdoes it, and something called a “cytokine storm”
could occur. This phenomenon is what is particularly dangerous about COVID-19
and often what causes hypoxia (low oxygen in the blood), low blood pressure,
worsening fever, and multi-organ damage. The second phase of infection is when
systemic [oral] steroids should be given. Low oxygen or a sudden change in
‘vital signs’ (BP, pulse, higher fever, decreased urination) should key the
doctor to prescribe steroids. Any other use is premature or unnecessary, and
can lead to secondary complications- not only mucor, but development or worsening of diabetes, significant
weight gain, hallucinations, weak bones, the list goes on.
Just to summarize- steroids are an
excellent medication, if used judiciously and in the appropriate situation. In
fact, they can be absolutely instrumental in changing the course of illness,
especially in COVID-19! However, one needs to keep the experts’ research and
latest clinical studies in mind when prescribing and/or buying for themselves
at the local chemist. It is absolutely understandable to want to reach for any
treatment possible when the fear of the pandemic looms overhead. But, if you
remember one point from this article- please keep in mind that over-medication
can be just as dangerous as the infection itself. Certainly, this can be kept
in mind for all medications going forward. Let this be a lesson to us all- evidence based medicine and proven
treatment protocols save lives!
By: Dr. Jennifer Prabhu, M.D.,
FAAP, FACP, MT(ASCP)
CEO and co-founder of Circee Health, Pvt. Ltd
